Cell Cycle Kinetics and Mitotically Linked Chemotherapy1
نویسنده
چکیده
Recent developments in the kinetics of solid and ascites tumors are discussed in terms of models of tumor growth and treatment with mitotically linked chemotherapeutic agents. Evidence for and the significance of the following phenomena are summarized: feedback control of cell proliferation in solid tumors, nonproliferating tumor cells, the reversion of tumor cells from nonproliferating to proliferating status, tumor cell death, clonogenic tumor cells, and changes of tumor kinetics in response to therapeutic perturbation.
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